The Use of Gene Therapy in Treating Genetic Diseases Before Birth: A Comprehensive Review

Authors: Dr. Yousif Abdullah Sayer AlAnazi

Country: Saudi Arabia

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Abstract: Gene therapy has emerged as a promising approach for treating genetic diseases, with the potential to intervene before birth to prevent or mitigate the effects of inherited disorders. This comprehensive review examines prenatal gene therapy's current state and prospects, focusing on its applications, techniques, and ethical considerations. Through a systematic analysis of literature published up to 2020, this study investigates the efficacy, safety, and challenges of in-utero gene therapy interventions. The findings reveal significant advancements in viral vector-mediated gene delivery, gene editing technologies, and our understanding of fetal development and immune responses. Additionally, the study highlights the potential of prenatal gene therapy in treating various genetic disorders, from single-gene defects to complex multifactorial conditions. This research underscores the rapid evolution of prenatal gene therapy and its implications for the future of fetal medicine and genetic disorder management.

Keywords: Prenatal gene therapy, in utero gene transfer, fetal gene editing, genetic diseases, viral vectors, CRISPR-Cas9, ethical considerations, fetal development

Paper Id: 230908

Published On: 2020-07-04

Published In: Volume 8, Issue 4, July-August 2020

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