Evaluating Biochemical Markers for Early Detection of Sepsis in ICU Patients: A Hospital-Based Study

Authors: Kholoud H. Aldubayan, Amal M. Hariri, Majed M. Alsharari, Samar A. Aldugeshem

DOI: https://doi.org/10.5281/zenodo.13627605

Short DOI: https://doi.org/gt88d4

Country: Saudi Arabia

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Abstract: Objective: This study aimed to evaluate the effectiveness of biochemical markers—C-reactive protein (CRP), procalcitonin (PCT), lactate, and interleukin-6 (IL-6)—in the early detection of sepsis in hospitalized patients.

Methods: A retrospective cohort study was conducted with 400 patients (200 with sepsis and 200 controls). Biochemical marker levels were measured at admission, and their diagnostic performance was assessed using receiver operating characteristic (ROC) curves. Clinical outcomes, including ICU admission, length of hospital stay, and 30-day mortality, were correlated with marker levels.

Results: Procalcitonin demonstrated the highest diagnostic accuracy (AUC = 0.91), followed by IL-6 (AUC = 0.89). CRP (AUC = 0.85) and lactate (AUC = 0.82) were also elevated in sepsis patients. Elevated levels of all markers were significantly associated with worse clinical outcomes, including higher ICU admission rates and increased 30-day mortality.

Conclusion: Procalcitonin and interleukin-6 are effective biomarkers for the early detection of sepsis and are associated with adverse outcomes. These markers can be valuable tools in the early diagnosis and management of sepsis, potentially improving patient outcomes through timely intervention.

Keywords: Sepsis, Procalcitonin, C-reactive Protein, Interleukin-6, Lactate, Biochemical Markers, Early Detection

Paper Id: 231102

Published On: 2018-08-07

Published In: Volume 6, Issue 4, July-August 2018

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