Evaluating the Effectiveness of Non-Invasive Ventilation in Obesity Hypoventilation Syndrome: A Retrospective Study on Clinical Outcomes

Authors: Hoda A. Khoutan, Wafa M. Al-Malack, Nahlah A. Albaalharith, Eman M. Alanizi, Abdullah G. Alshubaili, Aishah R. Alanazi, Abdulaziz S. Alaws

DOI: https://doi.org/10.5281/zenodo.13682505

Short DOI: https://doi.org/gt9jmr

Country: Saudi Arabia

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Abstract: Background: Obesity hypoventilation syndrome (OHS) is characterized by impaired ventilation leading to hypercapnia and disrupted sleep. Non-invasive ventilation (NIV) is commonly used to manage OHS, but its effectiveness in reducing hypercapnia and improving sleep quality requires further evaluation.
Objective: This study aimed to assess the impact of NIV on hypercapnia and sleep quality in patients with OHS.
Methods: We conducted a retrospective analysis of 50 OHS patients treated with NIV over a 6-month period. Clinical outcomes were measured through arterial blood gas analyses and polysomnography before and after NIV therapy. Data on PaCO2 levels, sleep efficiency, apnea-hypopnea index (AHI), and hypopnea index were collected and analyzed.
Results: NIV significantly reduced mean PaCO2 levels by 10.2 mmHg (p < 0.01). Improvements in sleep quality were observed, with sleep efficiency increasing by 8.3%, and AHI and hypopnea index decreasing by 37.2% and 37.4%, respectively.
Conclusion: NIV effectively decreases hypercapnia and enhances sleep quality in patients with OHS. These findings support the use of NIV as a beneficial intervention in managing OHS.

Keywords: Non-invasive ventilation, obesity hypoventilation syndrome, hypercapnia, sleep quality, arterial blood gas, polysomnography

Paper Id: 231120

Published On: 2023-04-04

Published In: Volume 11, Issue 2, March-April 2023

Cite This: Evaluating the Effectiveness of Non-Invasive Ventilation in Obesity Hypoventilation Syndrome: A Retrospective Study on Clinical Outcomes - Hoda A. Khoutan, Wafa M. Al-Malack, Nahlah A. Albaalharith, Eman M. Alanizi, Abdullah G. Alshubaili, Aishah R. Alanazi, Abdulaziz S. Alaws - IJIRMPS Volume 11, Issue 2, March-April 2023. DOI 10.5281/zenodo.13682505

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