Evaluation of Antiviral Resistance Patterns in Hospitalized Influenza Patients: A Retrospective Analysis in a Tertiary Hospital

Authors: Haneen K. Halawani, Asmaa S. Judeeba, Meaad A. Algaydi, Abrar F. Alharbi

DOI: https://doi.org/10.5281/zenodo.13888660

Short DOI: https://doi.org/g6zghf

Country: Saudi Arabia

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Abstract: Antiviral resistance poses a significant challenge in managing hospitalized patients with influenza. This retrospective cohort study aimed to evaluate the prevalence of antiviral resistance and its impact on clinical outcomes in 500 hospitalized patients with laboratory-confirmed influenza at a tertiary hospital over a five-year period. Genetic sequencing revealed that 10% of isolates carried resistance mutations, with the highest prevalence (15%) in the H1N1 subtype. Patients infected with resistant strains experienced worse outcomes, including higher ICU admissions (60% vs. 30%, p < 0.01), longer hospital stays (15.2 vs. 9.3 days, p < 0.01), and increased mortality (20% vs. 7.8%, p < 0.01). The findings underscore the need for routine surveillance of antiviral resistance and early adjustment of antiviral therapies to improve patient outcomes.

Keywords: antiviral resistance, influenza, hospitalized patients, oseltamivir, neuraminidase inhibitors, clinical outcomes, H1N1

Paper Id: 231291

Published On: 2024-06-05

Published In: Volume 12, Issue 3, May-June 2024

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