The Impact of Nutritional Status and Pharmacotherapy on Bone Health: A Radiological and Biochemical Approach in Osteoporosis Management

Authors: Aminah K Alanazi, Maryam H. Aldossari, Fahad Alenizy, Hessah A. Al Qadeeb, Bader H. Alanazi, Maha S. Gassas, Rania A. Sharaf, Amer S. Alhumaidan

DOI: https://doi.org/10.5281/zenodo.13922729

Short DOI: https://doi.org/g768pv

Country: Saudi Arabia

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Abstract: Background : Osteoporosis is a prevalent condition leading to decreased bone mineral density (BMD) and increased fracture risk. Nutritional supplementation and pharmacotherapy are essential for managing osteoporosis, but their combined impact requires further investigation.
Objective : This study assessed the effects of calcium and vitamin D supplementation alongside pharmacotherapy on BMD in osteoporosis patients, monitored through radiological and biochemical measures.
Methods : A prospective observational study was conducted with 200 osteoporosis patients at a tertiary hospital. Nutritional supplementation adherence, pharmacotherapy adherence, BMD changes (measured by DEXA scans), and biochemical markers (e.g., serum calcium, vitamin D, CTX) were evaluated over 12 months.
Results : Participants adhering to both supplementation and pharmacotherapy showed significant improvements in lumbar spine BMD (+7%) and femoral neck BMD (+6%). Adherence to calcium and vitamin D was positively correlated with BMD improvements (r = 0.62, p < 0.01). Reductions in CTX indicated decreased bone resorption.
Conclusion : The combination of nutritional supplementation and pharmacotherapy significantly improves bone health in osteoporosis patients. Adherence to both interventions is critical for achieving optimal BMD outcomes.

Keywords: Osteoporosis, bone mineral density, calcium, vitamin D, pharmacotherapy, DEXA, biochemical markers

Paper Id: 231317

Published On: 2017-07-07

Published In: Volume 5, Issue 4, July-August 2017

Cite This: The Impact of Nutritional Status and Pharmacotherapy on Bone Health: A Radiological and Biochemical Approach in Osteoporosis Management - Aminah K Alanazi, Maryam H. Aldossari, Fahad Alenizy, Hessah A. Al Qadeeb, Bader H. Alanazi, Maha S. Gassas, Rania A. Sharaf, Amer S. Alhumaidan - IJIRMPS Volume 5, Issue 4, July-August 2017. DOI 10.5281/zenodo.13922729

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