A Multidisciplinary Approach to Diagnosing and Managing Drug-Induced Liver Injury: The Role of Radiology, Pharmacotherapy, and Biomarkers in a Tertiary Hospital

Authors: Aminah K. Alanazi, Maryam H. Aldossari, Fahad Alenizy, Bader H. Alanazi, Ali A. Almalki, Salem A. Alharbi, Maha S. Gassas, Rania A. Sharaf, Zahra Asiri, Amer S. Alhumaidan

DOI: https://doi.org/10.5281/zenodo.13922735

Short DOI: https://doi.org/g7683q

Country: Saudi Arabia

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Abstract: Background : Drug-Induced Liver Injury (DILI) is a significant cause of acute liver failure and often requires a multidisciplinary approach for accurate diagnosis and effective management.
Objective : This study aimed to evaluate the combined role of radiological imaging, biomarkers, and pharmacotherapy in diagnosing and managing DILI in a tertiary hospital.
Methods : A retrospective observational study was conducted on 120 patients diagnosed with DILI. Radiological findings, biomarker levels (ALT, AST, bilirubin, cytokeratin-18, microRNA-122), and pharmacotherapy interventions were collected and analyzed.
Results : Hepatomegaly (35%) and fatty liver (25%) were the most common radiological findings, while ALT and AST elevations were observed in over 80% of patients. Emerging biomarkers, such as cytokeratin-18, were elevated in 80% of cases. Discontinuation of the offending drug led to recovery in 85% of patients, with N-acetylcysteine and corticosteroids showing positive outcomes in specific cases.
Conclusion : The integration of radiological imaging, biomarkers, and pharmacotherapy offers a comprehensive approach to diagnosing and managing DILI. Early intervention and a multidisciplinary strategy are critical for improving patient outcomes.

Keywords: Drug-Induced Liver Injury, DILI, radiological imaging, biomarkers, pharmacotherapy, ALT, AST, cytokeratin-18, N-acetylcysteine

Paper Id: 231318

Published On: 2018-07-10

Published In: Volume 6, Issue 4, July-August 2018

Cite This: A Multidisciplinary Approach to Diagnosing and Managing Drug-Induced Liver Injury: The Role of Radiology, Pharmacotherapy, and Biomarkers in a Tertiary Hospital - Aminah K. Alanazi, Maryam H. Aldossari, Fahad Alenizy, Bader H. Alanazi, Ali A. Almalki, Salem A. Alharbi, Maha S. Gassas, Rania A. Sharaf, Zahra Asiri, Amer S. Alhumaidan - IJIRMPS Volume 6, Issue 4, July-August 2018. DOI 10.5281/zenodo.13922735

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