The Association Between Liver Enzymes and Metabolic Syndrome in Obese Patients: A Cross-Sectional Study in a Tertiary Hospital

Authors: Abdulaziz S. Alshehri, Abdulaziz Y. Homadi, Amer S. Alhumaidan, Ahmed A. Shareefi, Maha S. Gassas, Ali A. Almalki, Bader H. Alanazi, Rania A. Sharaf, Mussab A. Alqahtani, Mohand S. Alsowaida

DOI: https://doi.org/10.5281/zenodo.13927294

Short DOI: https://doi.org/g8dvsb

Country: Saudi Arabia

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Abstract: Background: Metabolic syndrome is a cluster of metabolic disorders that increase the risk of cardiovascular diseases and type 2 diabetes, particularly in obese populations. Liver enzymes—alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT)—are often elevated in individuals with metabolic syndrome, but their relationship with specific metabolic components remains unclear.

Objective: This study aimed to investigate the relationship between liver enzyme levels and components of metabolic syndrome in obese patients at a tertiary hospital.

Methods: A cross-sectional study was conducted with 200 obese patients, 110 of whom were diagnosed with metabolic syndrome based on the NCEP ATP III criteria. Liver enzyme levels (ALT, AST, GGT) were measured and correlated with metabolic syndrome components, including waist circumference, fasting glucose, triglycerides, and HDL cholesterol. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the predictive value of liver enzymes for metabolic syndrome.

Results: Patients with metabolic syndrome had significantly higher ALT, AST, and GGT levels (p < 0.001) compared to those without metabolic syndrome. ALT and GGT were independently associated with the presence of metabolic syndrome (OR = 2.56, p < 0.001; OR = 2.78, p < 0.001, respectively). ALT and GGT showed moderate diagnostic accuracy, with AUC values of 0.74 and 0.77, respectively.

Conclusion: Elevated liver enzymes, particularly ALT and GGT, are significantly associated with metabolic syndrome in obese patients. These enzymes may serve as useful biomarkers for early detection and intervention in metabolic syndrome.

Keywords: Metabolic syndrome, obesity, liver enzymes, ALT, GGT, metabolic biomarkers, tertiary hospital

Paper Id: 231348

Published On: 2021-05-04

Published In: Volume 9, Issue 3, May-June 2021

Cite This: The Association Between Liver Enzymes and Metabolic Syndrome in Obese Patients: A Cross-Sectional Study in a Tertiary Hospital - Abdulaziz S. Alshehri, Abdulaziz Y. Homadi, Amer S. Alhumaidan, Ahmed A. Shareefi, Maha S. Gassas, Ali A. Almalki, Bader H. Alanazi, Rania A. Sharaf, Mussab A. Alqahtani, Mohand S. Alsowaida - IJIRMPS Volume 9, Issue 3, May-June 2021. DOI 10.5281/zenodo.13927294

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