Cassette Dosing in Drug Discovery: Advantages, Limitations, and Its Role in High-Throughput Pharmacokinetic Screening

Authors: Adinarayana Andy

DOI: https://doi.org/10.5281/zenodo.14059410

Short DOI: https://doi.org/g8qjqr

Country: USA

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Abstract: In early drug development, cassette dosing, also known as N-in-one dosing, has become more popular as a high-throughput pharmacokinetic screening technique. This method lets you quickly check the features related to absorption, distribution, metabolism, and excretion (ADME) by simultaneously giving several drug candidates to a single animal or a group of animals. Its main benefits are that it can efficiently screen vast chemical libraries, saving time and money and using fewer animals in preclinical trials. During the lead optimization stage, cassette dosing is beneficial when several analogs can be assessed to find viable options. It also facilitates biopharmaceutical classification and early toxicity assessments, which promote a more efficient medication development process.Despite its benefits, the method faces challenges, especially regarding potential compound interactions that may complicate data interpretation.Validating results thus requires careful study design and, when needed, additional single-compound trials. When paired with cutting-edge analytical methods such as LC-MS/MS, cassette dosing provides accurate, dependable, and reasonably priced pharmacokinetic screening. Cascade dosing is still a helpful approach in contemporary drug discovery despite several drawbacks. It facilitates the identification of promising drug candidates more quickly and helps pharmaceutical researchers make better-informed decisions at the beginning of the development process.

Keywords: Cassette dosing, pharmacokinetics, ADME, drug discovery, high-throughput screening.

Paper Id: 231469

Published On: 2019-06-05

Published In: Volume 7, Issue 3, May-June 2019

Cite This: Cassette Dosing in Drug Discovery: Advantages, Limitations, and Its Role in High-Throughput Pharmacokinetic Screening - Adinarayana Andy - IJIRMPS Volume 7, Issue 3, May-June 2019. DOI 10.5281/zenodo.14059410

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