The Role of Protein Binding in Drug Pharmacokinetics Implications for Drug Efficacy and Safety

Authors: Adinarayana Andy

DOI: https://doi.org/10.5281/zenodo.14059416

Short DOI: https://doi.org/g8qjqv

Country: USA

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Abstract: Protein binding is a critical factor in drug pharmacokinetics, significantly impacting drug absorption, distribution, metabolism, and excretion. This phenomenon refers to the reversible interaction between drugs and plasma proteins, such as albumin and alpha-1 acid glycoprotein, influencing drug efficacy and safety. A drug's free (unbound) fraction is pharmacologically active, while the bound fraction acts as a reservoir, modulating the drug's duration of action. Factors such as drug properties, protein levels, drug interactions, and pathological conditions can alter protein binding, leading to therapeutic effects and toxicity changes. Clinically, changing the dose and keeping an eye on the therapeutic drug are essential ways to handle drugs that bind to proteins, especially ones with a narrow therapeutic index, like warfarin and phenytoin. Understanding protein binding dynamics is also critical in drug development, ensuring optimal dosing regimens and minimizing the risk of adverse outcomes. This article explores the mechanisms and factors affecting protein binding and the clinical implications for drug efficacy and safety.

Keywords: Protein binding, free drug fraction, drug efficacy, drug safety, therapeutic drug monitoring (TDM)

Paper Id: 231470

Published On: 2019-10-03

Published In: Volume 7, Issue 5, September-October 2019

Cite This: The Role of Protein Binding in Drug Pharmacokinetics Implications for Drug Efficacy and Safety - Adinarayana Andy - IJIRMPS Volume 7, Issue 5, September-October 2019. DOI 10.5281/zenodo.14059416

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