Oral Microbiome Analysis in Patients with Dental Caries: A Comparative Study of Different Caries Risk Levels

Authors: Maram A. Alonayzan, Nourah A. AlHarethi, Rawabi A. Aldosary, Ebtesam A. Alamri, Faizah A. Garwi, Awadh M. Alanizi, Nada A. Alzahrani, Norah M. Alshatiri, Ahmed A. Aljabr

DOI: https://doi.org/10.5281/zenodo.14186587

Short DOI: https://doi.org/g8rfxq

Country: Saudi Arabia

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Abstract: Dental caries is a prevalent chronic condition influenced by various factors, including the oral microbiome. This study aimed to compare the oral microbiome composition between individuals with high and low caries risk in a tertiary hospital setting. A cross-sectional analysis was conducted involving 100 participants, with 16S rRNA sequencing used to determine microbial profiles. Results showed that high caries risk individuals exhibited significantly reduced microbial diversity and an increased abundance of cariogenic bacteria, such as *Streptococcus*, *Lactobacillus*, and *Veillonella*. The findings suggest that microbial profiling could serve as a predictive tool for caries susceptibility, supporting the ecological plaque hypothesis. Future research should focus on longitudinal studies to establish causal relationships and on exploring the functional aspects of the oral microbiome.

Keywords: Dental caries, oral microbiome, microbial diversity, cariogenic bacteria, caries risk, microbial profiling.

Paper Id: 231618

Published On: 2023-05-04

Published In: Volume 11, Issue 3, May-June 2023

Cite This: Oral Microbiome Analysis in Patients with Dental Caries: A Comparative Study of Different Caries Risk Levels - Maram A. Alonayzan, Nourah A. AlHarethi, Rawabi A. Aldosary, Ebtesam A. Alamri, Faizah A. Garwi, Awadh M. Alanizi, Nada A. Alzahrani, Norah M. Alshatiri, Ahmed A. Aljabr - IJIRMPS Volume 11, Issue 3, May-June 2023. DOI 10.5281/zenodo.14186587

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