The Role of Neuroimaging and Laboratory Biomarkers in Early Detection of Depression and Anxiety Disorders

Authors: Faisal M. AlSonbul, Noura I. Alrediny, Shahla S. Aldegheishem, Wafa I Alotaibi, Faisal E. Aljwuaied, Nourah M. Alorainy, Alanoud A. Abu taleb, Ali A. Alshehri

DOI: https://doi.org/10.5281/zenodo.14381558

Short DOI: https://doi.org/g8t99m

Country: Saudi Arabia

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Abstract: Background: Depression and anxiety disorders are prevalent mental health conditions requiring early detection for effective management. This study explored the synergistic potential of neuroimaging and laboratory biomarkers in diagnosing these disorders.

Methods: A cross-sectional study was conducted at a tertiary hospital involving 120 participants. Clinical assessments were combined with functional MRI and laboratory analysis of biomarkers, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and brain-derived neurotrophic factor (BDNF). Statistical analysis examined correlations between biomarkers and symptom severity.

Results: Elevated IL-6 and TNF-α levels were positively correlated with higher Hamilton Depression Rating Scale (HDRS) scores (r = 0.45, p = 0.01; r = 0.52, p = 0.002), while reduced BDNF levels were negatively correlated (r = -0.40, p = 0.03). These biomarkers were significant predictors of depression severity.

Conclusion: Integrating neuroimaging findings with laboratory biomarkers enhances diagnostic precision for depression and anxiety disorders. Future studies should validate these findings in larger cohorts to enable personalized therapeutic strategies.

Keywords: Depression, Anxiety, Neuroimaging, Biomarkers, IL-6, TNF-α, BDNF, Early Detection, Tertiary Hospital.

Paper Id: 231804

Published On: 2020-05-04

Published In: Volume 8, Issue 3, May-June 2020

Cite This: The Role of Neuroimaging and Laboratory Biomarkers in Early Detection of Depression and Anxiety Disorders - Faisal M. AlSonbul, Noura I. Alrediny, Shahla S. Aldegheishem, Wafa I Alotaibi, Faisal E. Aljwuaied, Nourah M. Alorainy, Alanoud A. Abu taleb, Ali A. Alshehri - IJIRMPS Volume 8, Issue 3, May-June 2020. DOI 10.5281/zenodo.14381558

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