Integrating Laboratory Data into Pharmacovigilance Systems: Enhancing Adverse Drug Reaction Detection and Patient Safety in a Tertiary Hospital

Authors: Alanoud A. Abu taleb, Maha I. Alonazi, Ali A. Alshehri, Faisal E. Aljwuaied, Chadah A. Alharbi

DOI: https://doi.org/10.5281/zenodo.14381761

Short DOI: https://doi.org/g8t997

Country: Saudi Arabia

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Abstract: Background: Integrating laboratory data into pharmacovigilance systems enhances the detection and prevention of adverse drug reactions (ADRs). This study evaluated the effectiveness of laboratory-integrated pharmacovigilance in a tertiary hospital setting.
Methods: A retrospective observational study was conducted on 1,200 patients. Laboratory data, including liver enzyme levels, renal function tests, and hematological parameters, were integrated with the pharmacovigilance system. Cases flagged for abnormal laboratory values were reviewed by pharmacists, and interventions were documented. Statistical analysis assessed the relationship between flagged values and confirmed ADRs.
Results: Of the 1,200 patients, 300 (25%) experienced ADRs, with 250 cases flagged by laboratory data. A high confirmation rate of 88% (220 cases) was observed, and 180 interventions (82% of confirmed ADRs) were performed. Hepatotoxicity and nephrotoxicity were the most common ADRs identified, with confirmation rates of 90% and 87.5%, respectively.
Conclusion: Integrating laboratory data into pharmacovigilance systems significantly improves ADR detection and facilitates timely clinical interventions. This approach demonstrates the potential to enhance patient safety and optimize therapeutic outcomes.

Keywords: Pharmacovigilance, Laboratory Data, Adverse Drug Reactions, Patient Safety, Tertiary Hospital, Health Informatics.

Paper Id: 231806

Published On: 2021-05-05

Published In: Volume 9, Issue 3, May-June 2021

Cite This: Integrating Laboratory Data into Pharmacovigilance Systems: Enhancing Adverse Drug Reaction Detection and Patient Safety in a Tertiary Hospital - Alanoud A. Abu taleb, Maha I. Alonazi, Ali A. Alshehri, Faisal E. Aljwuaied, Chadah A. Alharbi - IJIRMPS Volume 9, Issue 3, May-June 2021. DOI 10.5281/zenodo.14381761

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