Laboratory Interferences in Therapeutic Drug Monitoring: Implications for Accurate Pharmacological Decision-Making in Clinical Practice

Authors: Zaid A. Alhussain, Ahmed R. Alotaibi, Fatimah S. Alonazi, Ali A. Almalki

DOI: https://doi.org/10.5281/zenodo.14551428

Short DOI: https://doi.org/g8wtbc

Country: Saudi Arabia

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Abstract: Background: Laboratory interferences significantly impact the accuracy of therapeutic drug monitoring (TDM), leading to potential clinical consequences such as subtherapeutic dosing or toxicity. This study investigates the prevalence, types, and clinical implications of laboratory interferences in TDM within a tertiary hospital.
Methods: A six-month prospective study analyzed 300 samples submitted for TDM. Interferences were classified as endogenous, exogenous, or analytical artifacts, and their impact on drug concentrations and patient outcomes was evaluated. Qualitative insights from healthcare professionals provided additional context.
Results: Laboratory interferences were identified in 46.7% of samples, with endogenous factors being the most common (21.7%), followed by exogenous factors (13.3%) and analytical artifacts (11.7%). Clinically significant outcomes were observed in 13.3% of affected cases, including subtherapeutic dosing (6.0%) and toxicity (7.3%). Qualitative findings highlighted challenges in identifying and addressing interferences and emphasized the need for improved interdisciplinary communication and analytical techniques.
Conclusion: Laboratory interferences are prevalent in TDM and can lead to adverse clinical outcomes. Strategies such as enhanced analytical methods, interdisciplinary collaboration, and quality assurance measures are essential to mitigate these effects and improve patient safety.

Keywords: therapeutic drug monitoring, laboratory interferences, clinical outcomes, pharmacokinetics, matrix effects, patient safety, interdisciplinary collaboration.

Paper Id: 231897

Published On: 2016-01-06

Published In: Volume 4, Issue 1, January-February 2016

Cite This: Laboratory Interferences in Therapeutic Drug Monitoring: Implications for Accurate Pharmacological Decision-Making in Clinical Practice - Zaid A. Alhussain, Ahmed R. Alotaibi, Fatimah S. Alonazi, Ali A. Almalki - IJIRMPS Volume 4, Issue 1, January-February 2016. DOI 10.5281/zenodo.14551428

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