Advancing Personalized Medicine: The Role of Pharmacogenomics and Laboratory Diagnostics in Tailoring Medication Therapy

Authors: Ahmed R. Alotaibi, Fatimah S. Alotaibi, Manal A. Alonazi, Ali A. Almalki

DOI: https://doi.org/10.5281/zenodo.14551438

Short DOI: https://doi.org/g8ws92

Country: Saudi Arabia

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Abstract: Background: Pharmacogenomics has emerged as a critical tool in personalized medicine, offering the potential to tailor medication regimens based on an individual’s genetic profile. This study evaluates the clinical and economic impact of integrating pharmacogenomic testing and laboratory diagnostics into therapeutic decision-making in a tertiary hospital setting.
Methods: A prospective cohort study was conducted with 500 adult patients receiving medications with known pharmacogenomic relevance. Genetic variants were identified using next-generation sequencing, and laboratory diagnostics were utilized for therapeutic drug monitoring. Pharmacogenomic-guided interventions were implemented, and patients were followed for six months to assess clinical outcomes, medication adherence, and cost-effectiveness.
Results: Pharmacogenomic testing identified actionable genetic variants in 72% of patients, leading to personalized interventions. Adverse drug reactions decreased significantly from 28% to 12% (p < 0.001), while therapeutic efficacy improved from 65% to 85% (p < 0.001). Medication adherence increased by 20% (p = 0.002). Cost analysis revealed an average saving of $1,200 per patient due to reduced ADR-related hospitalizations and enhanced treatment efficiency.
Conclusions: Integrating pharmacogenomic testing and laboratory diagnostics into routine care improves clinical outcomes, enhances patient satisfaction, and offers significant economic benefits. This approach underscores the transformative potential of pharmacogenomics in advancing personalized medicine in tertiary care settings.

Keywords: Pharmacogenomics, Personalized Medicine, Laboratory Diagnostics, Adverse Drug Reactions, Tertiary Hospital, Cost-Effectiveness, Genetic Testing, Therapeutic Drug Monitoring

Paper Id: 231898

Published On: 2017-01-10

Published In: Volume 5, Issue 1, January-February 2017

Cite This: Advancing Personalized Medicine: The Role of Pharmacogenomics and Laboratory Diagnostics in Tailoring Medication Therapy - Ahmed R. Alotaibi, Fatimah S. Alotaibi, Manal A. Alonazi, Ali A. Almalki - IJIRMPS Volume 5, Issue 1, January-February 2017. DOI 10.5281/zenodo.14551438

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