Hematological Changes in Cancer Patients Undergoing Chemotherapy: A Comprehensive Evaluation of Diagnostic Trends and Pharmacological Interventions in a Tertiary Care Setting

Authors: Ahmed R. Alotaibi, Fatimah S. Alotaibi, Manal A. Alonazi

DOI: https://doi.org/10.5281/zenodo.14551456

Short DOI: https://doi.org/g8wtbf

Country: Saudi Arabia

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Abstract: Background: Hematological toxicities are common adverse effects of chemotherapy, significantly impacting treatment outcomes and patient safety. This study evaluates the prevalence, severity, and management of hematological changes in cancer patients undergoing chemotherapy in a tertiary hospital.
Methods: A prospective observational study was conducted on 200 patients receiving chemotherapy. Hemoglobin levels, absolute neutrophil counts (ANC), and platelet counts were monitored pre- and post-treatment. Supportive care interventions, including granulocyte colony-stimulating factors (G-CSFs) and erythropoiesis-stimulating agents (ESAs), were evaluated for their effectiveness.
Results: Significant declines in hematological parameters were observed post-chemotherapy (P < 0.001). Neutropenia (40%) and anemia (40%) were the most severe toxicities, leading to dose reductions (36%) and treatment delays (29%). G-CSFs facilitated 84% neutrophil recovery, while ESAs restored hemoglobin in 70% of cases. Despite these toxicities, 77% of patients completed their planned chemotherapy, and 68% reported quality of life improvements.
Conclusion: Chemotherapy-induced hematological toxicities are prevalent but manageable with timely supportive care interventions. Integrating routine laboratory monitoring with pharmacological strategies can optimize treatment delivery and patient outcomes.

Keywords: Chemotherapy, Hematological toxicities, Neutropenia, Anemia, Supportive care, Granulocyte colony-stimulating factors (G-CSFs), Tertiary care.

Paper Id: 231899

Published On: 2018-01-09

Published In: Volume 6, Issue 1, January-February 2018

Cite This: Hematological Changes in Cancer Patients Undergoing Chemotherapy: A Comprehensive Evaluation of Diagnostic Trends and Pharmacological Interventions in a Tertiary Care Setting - Ahmed R. Alotaibi, Fatimah S. Alotaibi, Manal A. Alonazi - IJIRMPS Volume 6, Issue 1, January-February 2018. DOI 10.5281/zenodo.14551456

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