Polycyclic Compounds in Microtubule Stabilization: Stereochemical and Structural Analysis

Authors: Tichakunda Xavier Mharazanye, Pratibha Sharma, Sushant Sharma, Shivangi Sharma, Sushant Gore, Shalu Kashyap, Vishal Kajla

Country: INDIA

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Abstract: The stereochemistry and structural characteristics of polycyclic molecules that prevent microtubule disintegration, a crucial target for cancer treatments. It investigates how these inhibitors, especially new substances like MP-HJ-1b and CB694, exhibit strong anticancer effects by disrupting microtubules and stopping the growth of tumour cells. The work also highlights how crucial structural and stereochemical investigations are to comprehending the mechanisms of action, binding selectivity, and interactions of these inhibitors with tubulin. To clarify the 3D structures and stereochemistry of these compounds and provide information on their molecular conformation and biological activity, essential methods such as X-ray crystallography and 2D- NMR spectroscopy are essential. The article also discusses the difficulties in analyzing polycyclic systems because of their complex stereochemical variability and the incorporation of computational methods, which improve the design of more effective anticancer agents. Knowledge of the structure-activity relationships and binding mechanisms lays the groundwork for the development of powerful cancer therapies that target microtubules, thereby addressing problems such as drug toxicity and multidrug resistance.

Keywords: Microtubule inhibitors, Polycyclic compounds, Stereochemistry, X-ray crystallography, 2D-NMR spectroscopy

Paper Id: 232045

Published On: 2025-01-24

Published In: Volume 13, Issue 1, January-February 2025

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